![]() ![]() It is usually incorporated into the first-line treatment, either as a single or a tandem auto-HCT. The leading cause of failure was disease progression of MM, which correlated with a shorter interval from the penultimate auto-HCT to the first relapse.Īutologous hematopoietic cell transplantation (auto-HCT) is the standard of care in the treatment of eligible patients with multiple myeloma. In conclusion, salvage auto-HCT performed with cells remobilized after a previous auto-HCT was associated with acceptable NRM. ![]() ![]() In multivariable analysis an increasing interval between the penultimate auto-HCT and relapse was associated with better OS and PFS, later calendar year of salvage auto-HCT with better OS. Overall survival (OS) after 2 and 4 years was 76 and 52%, progression-free survival (PFS) 39 and 15%. The 2- and 4-year non-relapse mortality (NRM) after the salvage auto-HCT was 5 and 9%, the relapse incidence 56 and 76%, respectively. The median time to relapse after the first-line penultimate auto-HCT(s) was 30.6 months, the median follow-up after salvage auto-HCT 31 months. There were 305 patients, 68% male, median age at salvage auto-HCT was 59 years. This retrospective study included patients who, following disease relapse after the first auto-HCT(s), underwent stem cell remobilization and auto-HCT performed using these cells. For those without an adequate dose of stored stem cells, remobilization is necessary. Ibrahim Yakoub-Agha ORCID: /0000-0003-4524-8782 23īone Marrow Transplantation volume 57, pages 633–640 ( 2022) Cite this articleĪutologous hematopoietic cell transplantation (auto-HCT) may be performed in multiple myeloma (MM) patients relapsing after a previous auto-HCT.Autologous hematopoietic cell transplantation for relapsed multiple myeloma performed with cells procured after previous transplantation–study on behalf of CMWP of the EBMT ![]()
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